The Effect of Fluoroquinolones on the Disease-Free Interval in Patients with Stage Ta Transitional Cell Carcinoma of the Bladder, Phase III

Pts must have Stage Ta (any grade) transitional cell carcinoma of the bladder by cystoscopy (within 42 days). Pts w/ recurrent bladder disease must not have had a diagnosis greater than (or equal to) T2. Patients who are high risk for upper tract (ureter or renal/pelvic) transitional cell cancers are not eligible. Prior radiation therapy and/or intravesical therapy is allowed provided 28 days have elapsed and there are no toxicities. Pts must not be receiving hemo or peritoneal dialysis. Pts must not be allergic to fluoroquinolones. Pts must not be currently taking or have taken fluoroquinolone within 3 months of the cytoscopy. If pt allergic to penicillin or cephalosporin, pt must be able to take sulfamethoxazole/trimethoprim. Pts must not be currently taking probenecid or theophylline. All pts stratified as having recurrent disease must agree to submission of bladder washing samples (at time of TURBT).