A Randomized Trial Assessing the Effects of Exercise on Patients with Locally Advanced Lung Cancer Undergoing Curative Intent Combined Modality Therapy

Pts must have unresectable Stage IIIA (N2) or Stage IIIB lung cancer of any histology including small cell lung cancer. All pts must have received platin-based chemo & RT (>4,500cGy using CT planning)and recovered from acute side effects. All pts must be re-staged 4-8 wks after completion of treatment and have CR/PR/SD at re-staging to be eligible. Pts must be willing to take part in an exercise program of 12 wks including F/U visits if they are randomized to that arm of the study. Pts must have a Zubrod PS 0-2 and be physically capable of participating. No uncontrolled cardiac disease, recent MI, uncontrolled diabetes mellitus or any other medical conditions that would preclude part in the exercise program. Pts with chemotherapy induced neuropathy must have <= Grade 2 by CTCAE Version 3.0. PFT must be performed w/in 28 days prior to reg. Pts must be able to read and understand English in order to participate in the QOL portion of the study. Pts unable to read and understand English may be reg to receive the exercise or standard medical management intervention w/o completing the QOL questionnaire. Pts able to read and understand English must have completed the FACT-L TOI no more than 14 days before reg. The nurse or CRA must have completed the QOL Cover Sheet for the pre-study assessment.