Smoking Cessation Intervention (Including Bupropion-Zyban Versus Placebo) for Completely Resected Stage I and Stage II Non-Small Cell Lung Cancer Survivors Who Are Currently Smokers, Phase III

Pt must be dx'd w/Stage I or II NSCLC and be free of recurrent or progressive disease. Pt must have complete resection of all disease. Pt may rec concurrent adj chemo and/or RT or may have rec'd neoadj therapy. Pt must have a Zubrod PS of 0-2. Pt must be a current smoker as defined in Section 5.5 of the protocol. Pt must establish a quit date prior to reg which falls w/in 30 days after reg. Pts in the immediate post-infarction period, pts w/uncontrolled arrhythmias and pts w/unstable angina are not eligible. If pt has hypertension, it must be adequately controlled. Pt must not have a hx of seizures or eating disorders. Pt must not be taking any concomitant medications that lower seizure threshold. Pt must be able to read, speak and understand English. Pt must not have a current psychiatric dx that would interfere w/ability to participate in the intervention. Pt must not be rec'd or planning to rec any other medications that contain bupropion, any form of nicotine replacement therapy, or any other antidepressant or antipsychotic medication. There must be no known drug-drug interaction between nicotine and/or bupropion w/ pt's current or planned medications. Pt must have completed baseline packet of questionnaires. Pt must be willing to have saliva testing for cotinine levels. Pt must be offered participation on the correlative studies outlined in Section 15.1.

CANCER CONTROL CREDIT: 0.7
TREATMENT CREDIT: 0.0