SWOG clinical trial number
C89803

A Phase III Intergroup Trial of Irinotecan (CPT-11) (NSC-616348) Plus Fluorouracil/Leucovorin (5FU/LV) Versus Fluorouracil/Leucovorin Alone After Curative Resection For Patients With Stage III Colon Cancer.

Closed
Phase
Published
Abbreviated Title
COLON
Activated
07/15/2000
Closed
05/15/2001
Participants
NCORP, Members, Pathologists

Research committees

Gastrointestinal Cancer

Treatment

Irinotecan Leucovorin + 5-FU

Eligibility Criteria Expand/Collapse

Histologic documentation of adenocarcinoma of the colon. The gross inferior (caudad) margin of the primary tumor must lie above the peritoneal reflection. Completely resected tumor, including negative radial resecting margins. Pathologically documented Modified Astler-Coller Stage C (Tx N1-2 M0). No history of distant metastatic dz at time of registration. No prior chemotherapy or radiotherapy for this malignancy. No previous or concurrent malignancy, non-pregnant, non-nursing. Granulocytes > = 1,500/uL, platelet > = 100,000/uL, creatinine < = 1.5 x upper limit of normal (ULN), bilirubin < = ULN.

Publication Information Expand/Collapse

2019

The influence of dietary insulin load on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803 (Alliance)

V Morales-Oyarvide;C Yuan;A Babic;S Zhang;D Niedzwiecki;JC Brand-Miller;L Sampson-Kent;X Ye;Y Li;L Saltz;RJ Mayer;RB Mowat;R Whittom;A Hantel;A Benson;D Atienza;M Messino;H Kindler;A Venook;S Ogino;K Wu;WC Willet;EL Giovannucci;BM Wolpin;JA Meyerhardt;CS Fuchs;K Ng Journal of the National Cancer Institute Feb 1;111(2):170-179

PMid: PMID30726946 | PMC number: PMC6376913

2018

Marine omega-3 polyunsaturated fatty acid and fish intake after colon cancer diagnosis and survival: CALGB 89803 (Alliance)

E Van Blarigan;CS Fuchs;D Niedzwiecki;X Ye;S Zhang;M Song;LB Saltz;RJ Mayer;RB Mowat;R Whittom;A Hantel;AB Benson;D Atienza;M Messino;H Kindler;A Venook;S Ogino;WC Willett;EL Giovannucci;JA Meyerhardt Cancer Epidemiology, Biomarkers and Prevention Apr;27(4):438-445;Jan 22 [Epub ahead of print]

PMid: PMID29358223 | PMC number: PMC5939380

Associations of artificially sweetened beverage intake with disease recurrence and mortality in stage III colon cancer: Results from CALGB 89803 (Alliance)

B Guercio;S Zhang;D Niedzwiecki;Z Yee;Y Li;A Babic;V Morales-Oyarvide;L Saltz;RJ Mayer;R Mowat;R Whittom;A Hantel;A Benson;DM Atienza;M Messino;H Kindler;A Venook;S Ogino;E Zoltick;M Stempfer;K Ng;K Wu;W Willett;E Giovannucci;J Meyerhardt;C Fuchs PLOS ONE Jul 19;13(7):e0199244

PMid: PMID30024889 | PMC number: PMC6053135

Association of Survival With Adherence to the American Cancer Society Nutrition and Physical Activity Guidelines for Cancer Survivors After Colon Cancer Diagnosis: The CALGB 89803/Alliance Trial

E Van Blarigan;C Fuchs;D Niedzwiecki;X Ye;S Zhang;L Saltz;R Mayer;R Mowat;R Whittom;A Hantel;A Benson;D Atienza;M Messino;H Kindler;A Venook;S Ogino;E Giovannucci;K Ng;J Meyerhardt JAMA Oncology Jun 1;4(6):783-790; Apr 12. doi: 10.1001/jamaoncol.2018.0126. [Epub ahead of print]

PMid: PMID29710284 | PMC number: PMC6145685

Grain Intake and Clinical Outcome in Stage III Colon Cancer: Results from CALGB 89803 (Alliance)

JC Brown;S Zhang;D Niedzwiecki;L Saltz;R Mayer;RB Mowat;R Whittom;A Hantel;A Benson;M Messino;D Atienza;H Kindler;A Venook;S Ogin;Y Li;X Zhang;K Ng;W Willett;E Giovannucci;C Fuchs;J Meyerhardt JNCI Cancer Spectrum Feb;2(2); Epub 2018 May 30

PMid: PMID29877501 | PMC number: PMC5977856

Nut consumption and survival in patients with stage III colon cancer: results from CALGB 89803 (Alliance)

T Fadelu;S Zhang;D Niedzwiecki;X Ye;L Saltz;R Mayer;R Mowat;R Whittom;A Hantel;A Benson;D Atienza;M Messino;H Kindler;A Venook;S Ogino;K Ng;K Wu;W Willett;E Giovannucci;J Meyerhardt;Y Bao;C Fuchs Journal of Clinical Oncology Apr 10;36(11):1112-1120; Feb 28 [Epub ahead of print]

PMid: PMID29489429 | PMC number: PMC5891130

Dietary fat intake after colon cancer diagnosis in relation to cancer recurrence and survival

E Van Blarigan;C Fuchs;F-S Ou;D Niedzwiecki;S Zhang;L Saltz;RJ Mayer;A Hantel;A Venook;S Ogino;M Song;E Giovannucci;J Meyerhardt Cancer Epidemiol Biomarkers Prevention Oct;27(10):1227-1230

PMid: PMID30038051 | PMC number: PMC6170705

2017

Long-chain omega-3 fatty acid and fish intake after colon cancer diagnosis and disease-free, recurrence-free, and overall survival in CALGB 89803 (Alliance)

EL Van Blarigan;C Fuchs;D Niedzwiecki;X Ye;S Zhang;M Song;L Saltz;R Mayer;RB Mowat;R Whittom;A Hantel;A Benson;D Atienza;M Messino;M Kindler;A Venook;S Ogino;W Willett;EL Giovannucci;JA Meyerhardt Journal of Clinical Oncology 35, 2017 (suppl 4S; abstract 585); ASCO GI Cancers Symposium (January 19-21, 2017, San Francisco, CA), poster

American cancer society (ACS) nutrition and physical activity guidelines after colon cancer diagnosis and disease-free (DFS), recurrence-free (RFS), and overall survival (OS) in CALGB 89803 (Alliance)

E Van Blarigan;C Fuchs;D Niedzwiecki;X Ye;S Zhang;M Song;L Saltz;RJ Mayer;RB Mowat;R Whittom;A Hantel;A Benson;D Atienza;M Messino;H Kindler;A Venook;S Ogino;W Willett;EL Giovannucci;J Meyerhardt J Clin Oncol 35, 2017 (suppl; abstr 10006); American Society of Clinical Oncology Annual Meeting (June 2-6, 2017, Chicago, IL), oral presentation

Nut consumption and survival in stage III colon cancer patients: results from CALGB 89803 (Alliance)

T Fadelu;D Niedzwiecki;S Zhang;X Ye;L Saltz;R Mayer;R Mowat;R Whittom;A Hantel;A Benson;D Atienza;M Messino;H Kindler;A Venook;S Ogino;K Ng;E Giovannucci;J Meyerhardt;Y Bao;C Fuchs J Clin Oncol 35, 2017 (suppl; abstr 3517); American Society of Clinical Oncology Annual Meeting (June 2-6, 2017, Chicago, IL), poster session

Predicted vitamin D status and colon cancer recurrence and mortality in CALGB 89803 (Alliance)

M Fuchs;C Yuan;K Sato;D Niedzwiecki;X Ye;L Saltz;RJ Mayer;R Mowat;R Whittom;A Hantel;A Benson;D Atienza;M Messino;H Kindler;A Venook;F Innocenti;RS Warren;M Bertagnolli;S Ogino;E Giovannucci;E Horvath;J Meyerhardt Annals of Oncology Jun 1;28(6):1359-1367

PMid: PMID28327908 | PMC number: PMC578980

2015

Aspirin and COX-2 inhibitor use in patients with stage III colon cancer.

K Ng;J Meyerhardt;J Chan;D Niedzwiecki;L Saltz;R Mayer;A Benson;P Schaefer;R Whittom;A Hantel;R Goldberg;A Venook;S Ogino;E Giovannucci;C Fuchs Journal of the National Cancer Institute, 2014 Nov 27;107(1):345. doi: 10.1093/jnci/dju345; Print Jan 2015 Jan

PMid: PMID25432409 | PMC number: PMC4271076

Coffee intake, recurrence and mortality in stage III colon cancer: results from CALGB 89803 (Alliance)

BJ Guercio;K Sato;D Niedzwiecki;L Saltz;RJ Mayer;RB Mowat;R Whittom;A Hantel;A Benson;D Atienza;MJ Messino;H Kindler;A Venook;FB Hu;S Ogino;K Wu;B Willett;E Giovannucci;JA Meyerhardt;C Fuchs Journal of Clinical Oncology, Nov 1;33(31):3598-3607

PMid: PMID26282659 | PMC number: PMC4622099

2014

Sugar-sweetened beverage intake and cancer recurrence and survival in CALGB 89803 (Alliance)

M Fuchs;K Sato;D Niedzwiecki;X Ye;LB Saltz;RJ Meyer;RB Mowat;R Whittom;A Hantel;A Benson;D Atienza;M Messino;H Kindler;A Venook;S Ogino;K Wu;WC Willett;EL Giovannucci;JA Meyerhardt PLOS ONE 9(6):e99816;

PMid: PMID24512953 | PMC number: PMC4019685

2013

Comparison of dietary and lifestyle habits among stage III and metastatic colorectal cancer patients: findings from CALGB 89803 and CALGB 80405

K Van Loon;D Wigler;D Niedzwiecki;AP Venook;C Fuchs;C Blanke;L Saltz;RM Goldberg;JA Meyerhardt Clinical Colorectal Cancer 12(2):95-102;

PMid: PMID23317558 | PMC number: PMC3790266

Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial

S Ogino;X Liao;Y Imamura;M Yamauchi;N McCleary;K Ng;D Niedzwiecki;L Saltz;RJ Mayer;R Whittom;A Hantel;A Benson;RB Mowat;D Spiegelman;RM Goldberg;M Bertagnolli;JA Meyerhardt;C Fuchs Journal of the National Cancer Institute 105(23):1789-1798;

PMid: PMID24231454 | PMC number: PMC384898

Impact of physical activity after cancer diagnosis on survival in patients with recurrent colon cancer: findings from CALGB 89803/Alliance

J Jeon;K Sato;D Niedzwiecki;X Ye;LB Saltz;RJ Mayer;RB Mowat;R Whittom;H Hantel;A Benson;D Wigler;D Atienza;M Messino;H Kindler;A Venook;C Fuchs;J Meyerhardt Clinical Colorectal Cancer 12(4):233-238;

PMid: PMID24035029 | PMC number: PMC3818492

2012

Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from the intergroup trial CALBG 89803 [PMID22147942; PMC3271172]; https://www.ncbi.nlm.nih.gov/pubmed/22147942

S Ogino;K Shima;J Meyerhardt;NJ McCleary;K Ng;L Saltz;R Mayer;P Schaefer;R Whittom;A Hantel;A Benson;D Spiegelman;R Goldberg;M Bertagnolli;C Fuchs Clinical Cancer Research 18(3):890-900

Dietary glycemic load and cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803

JA Meyerhardt;K Sato;D Niedzwiecki;C Ye;L Saltz;RJ Mayer;RB Mowat;R Whittom;A Hantel;A Benson;D Wigler;A Venook;C Fuchs Journal of the National Cancer Institute 104(22):1702-1711

PMid: PMID23136358 | PMC number: PMC3502194

2011

Relationship between statin use and colon cancer recurrence and survival: results from CALGB 89803 [PMID21849660;PMC3196479]

K Ng;S Ogino;JA Meyerhardt;AT Chan;D Niedzwiecki;D Hollis;LB Saltz;RJ Mayer;AB Benson;P Schaefer;R Whittom;A Hantel;RM Goldberg;M Bertagnolli;AP Venook;C Fuchs Journal of the National Cancer Institute 103(20):1540-1551;

2010

Multivitamin use is not associated with cancer recurrence or survival in patients with Stage III colon cancer: findings from CALGB 89803 [PMID20805450; PMC2954134]

K Ng;JA Meyerhardt;JA Chan;D Niedzwiecki;DR Hollis;LB Saltz;RJ Mayer;AB Benson;PL Schaefer;R Whittom;A Hantel;RM Goldberg;C Fuchs Journal of Clinical Oncology, 28(29):4354-4363;

Impact of smoking on patients with stage III colon cancer: results from Cancer and Leukemia Group B 89803 [PMC2884300; PMID20052723]

NJ McCleary;D Niedzwiecki;D Hollis;LB Saltz;P Schaefer;R Whittom;A Hantel;A Benson;R Goldberg;JA Meyerhardt Cancer 116(4):957-966

2009

KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803 [PMC2787689; PMID19934290]

S Ogino;JA Meyerhardt;D Niedzwiecki;D Hollis;L Saltz;RJ Mayer;P Schaefer;R Whittom;A Hantel;AB Benson;RM Goldberg;M Bertagnolli;C Fuchs Clinical Cancer Research 15(23):7322-7329

2008

Association of family history with cancer recurrence and survival among patients with stage III colon cancer [PMID18523220; NIHMS277201]

JA Chan;JA Meyerhardt;D Niedzwiecki;D Hollis;LB Saltz;RJ Mayer;J Thomas;PL Schaefer;R Whittom;A Hantel;RM Goldberg;RS Warren;M Bertagnolli;C Fuchs Journal of the American Medical Association 299(21):2515-2523

Impact of body mass index and weight change after teatment on cancer recurrence and survival in patients with stage III colon cancer: findings from Cancer and Leukemia Group B 89803. [PMC2654367; PMID18757324]

JA Meyerhardt;D Niedzwiecki;D Hollis;LB Saltz;RJ Mayer;H Nelson;R Whittom;A Hantel;J Thomas;J Thomas;C Fuchs Journal of Clinical Oncology 26(25):4109-4115

2007

Association of dietary patterns with cancer recurrence and survival in patients with stage III colon cancer

JA Meyerhardt;D Niedzwiecki;D Hollis;LB Saltz;FB Hu;RJ Mayer;H Nelson;R Whittom;A Hantel;J Thomas;CS Fuchs Journal of the American Medical Association 298(7):754-764

PMid: PMID17699009

Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: results of CALGB 89803

LB Saltz;D Niedzwiecki;D Hollis;RM Goldberg;RM Goldberg;A Hantel;JP Thomas;AL Fields;RJ Mayer Journal of Clinical Oncology 25(23):3456-3461

PMid: PMID17687149

2006

Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803

JA Meyerhardt;D Heseltine;D Niedzwiecki;D Hollis;LB Saltz;RJ Mayer;J Thomas;H Nelson;R Whitton;A Hantel;RL Schilsky;CS Fuchs Journal of Clinical Oncology 24(22):3535-3541

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Research Committee(s)
Gastrointestinal Cancer
Symptom Control and Quality of Life
Activated
06/15/2016
Open
Phase
III