SWOG clinical trial number
CTSU/A051301

A Randomized Double-Blind Phase III Study of Ibrutinib During and Following Autologous Stem Cell Transplantation Versus Placebo in Patients with Relapsed or Refractory Diffuse Large B-cell Lymphoma of the Activated B-cell Subtype

Closed
Phase
Abbreviated Title
Phase III of ibrutinib vs placebo in relapsed or refractory DLBCL of the active b-cell subtype
Status Notes
A051301 has been permanently closed to accrual effective 12/20/2022.
Activated
07/06/2016
Closed
12/20/2022
Participants
CTSU

Research committees

Lymphoma

Treatment

Ibrutinib

Publication Information Expand/Collapse

2025

Ibrutinib added to standard conditioning and as maintenance therapy following autologous hematopoietic stem cell transplantation for relapsed or refractory activated-B-cell type Diffuse Large B-cell lymphoma: primary analysis of the US intergroup double-blind randomized phase III study Alliance A051301/BMT-CTN 1201

B Andreadis;N Bartlett;J Leonard;P Stiff;J Friedberg;TBA Leuk Lymphoma. 2025 Oct;66(10):1903-1912. doi: 10.1080/10428194.2025.2525982. Epub 2025 Jul 9.NIHMS2093959

PMid: PMID40632607 | PMC number: PMC12321088

2023

Ibrutinib Added to Standard Conditioning and As Consolidation Therapy Following Autologous Hematopoietic Stem Cell Transplantation (AutoHCT) for Relapsed/Refractory Activated-B-Cell Subtype Diffuse Large B-Cell Lymphoma (ABC-DLBCL): Primary Analysis of the US Intergroup Double-Blind Randomized Phase III Study Alliance A051301/BMT-CTN 1201

C Andreadis;O Bobek;E Hsi;T Fenske;S Geyer;P Stiff;B Till;M Horwitz;F Khimani;R Little;S Dinner;J Friedberg;B Kahl;M Perales;S Devine;J Leonard;N Bartlett ASH Annual Meeting (Dec9-12,2023, San Diego, CA), oral

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