Concept Call for ComboMatch
SWOG investigators with concepts for the ComboMATCH NCI precision medicine trial can submit them now.
ComboMATCH is an iteration of MATCH, the precision trial run by ECOG-ACRIN. While MATCH treatments consist of single agents, ComboMATCH will test combinations of targeted agents, seeking higher response rates.
Sub-studies for ComboMATCH should include drug pairings that are supported with some preclinical or early clinical data and be based on a genomic selection marker, consistent with other precision medicine trials. Sub-studies may also need to be designed to separate activity of one or both agents from the effects of the combination – and multiple stages might be built in.