SWOG clinical trial number
SWOG-9402

Phase III Intergroup Randomized Comparison of Radiation Alone Vs. Pre-Radiation Chemotherapy for Pure and Mixed Anaplastic Oligodendrogliomas

Closed
Phase
Published
Abbreviated Title
Pure and Mixed Anaplastic Oligodendroglioma
Activated
09/01/1994
Closed
03/29/2002
Participants
NCORP, Members, Medical Oncologists, Radiation Oncologists, Pathologists

Research committees

Brain Cancer

Treatment

Radiation Therapy PCV

Eligibility Criteria Expand/Collapse

Pathologic evidence of unifocal or multifocal supratentorial pure or mixed anaplastic oligodendroglioma; patients with low grade glioma are eligible provided they now have a biopsy proven pure or mixed anaplastic oligodendroglioma and have not been treated previously with either RT or chemo; KPS >= 60, AGC >=1,500/µl, platelet count >=150,000/µl, creatinine < / = 1.5 x normal, bilirubin, SGOT, alkaline phos.< / = 2 x normal; no prior RT or chemotherapy.

Publication Information Expand/Collapse

2023

Higher vincristine doses correlate with longer overall survival: a post-hoc analysis of participants receiving PCV on RTOG 9402

M Donovan;K Fink;M Mehta Society for Neuro-Oncology Annual Meeting (SNO) (August 10-12, 2023, San Francisco, CA), poster

2021

Cognitive Function And Quality Of Life In Long Term Survivors Of RTOG 9402

L Donavan;M Won;J Cairncross;F Iwamoto;J Buckner;K Fink;J-P Bahary;A Hartford;L Souhami;T Nguyen;T Cescon;M Mishra;I Barani;A Pu;W Roa;J Huang;M Polley;M Mehta Society for Neuroncology (SNO) Annual Meeting (November 18-21, 2021, Boston), oral

2010

Cognition and quality of life after chemotherapy plus radiotherapy (RT) vs. RT for pure and mixed anaplastic olilgodendrogliomas: radiation therapy oncology group trial 9402 (RTOG; NCCTG; SWOG; NCIC CTG; ECOG) [PMID19783377; PMC2878934]

M Wang;JG Cairncross;E Shaw;R Jenkins;B Scheithauer;D Brachman;J Buckner;K Fink;L Souhami;N Laperriere;M Mehta;W Curran International Journal of Radiation Oncology, Biology and Physics 77(3):662-669

2006

Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402

G Cairncross;B Berkey;E Shaw;R Jenkins;B Scheithauer;D Brachman;J Buckner;K Fink;L Souhami;N Laperierre;M Mehta;W Curran Journal of Clinical Oncology 24(18):2707-2714

2004

An intergroup randomized controlled clinical trial (RCT) of chemotherapy plus radiation (RT) versus RT alone for pure and mixed anaplastic oligodendrogliomas: initial report of RTOG 94-02

G Cairncross;W Seiferheld;E Shaw;R Jenkins;B Scheithauer;D Brachman;J Buckner;K Fink;L Souhami;W Curran Proc of the American Society of Clinical Oncology 23:107 (#1500)