SWOG clinical trial number
SWOG-9008 (INT-0116) (RTOG-9018) (NCCTG-90-41-51) (ECOG-6290) (CALGB-9195)

Trial of Adjuvant Chemoradiation After Gastric Resection For Adenocarcinoma, Phase III

Abbreviated Title
Trial of Adjuvant Chemoradiation After Gastric Resection For Adenocarcinoma, Phase III

Research committees

Gastrointestinal Cancer



Publication Information Expand/Collapse


Survival by Hispanic Ethnicity among Cancer Patients Participating in SWOG Clinical Trials

M Chavez-MacGregor;J Unger;A Moseley;S Ramsey;DL Hershman Cancer Apr 15;124(8):1760-1769; Jan 25 [Epub ahead of print]

PMid: PMID29370458 | PMC number: PMC5963502

Survival by Hispanic Ethnicity Among Cancer Patients participating in SWOG Clinical Trials

A Moseley;M Chavez-MacGregor;J Unger;S Ramsey;D Hershman Society for Clinical Trials Annual Meeting (May 20-23 2018, Portland, OR), oral presentation


The effect of positive SWOG treatment trials on survival of patients with cancer in the US population

JM Unger;M Leblanc;CD Blanke JAMA Oncology Oct 1;3(10):1345-1351

PMid: PMID28586789; PMC5710507

The impact of positive SWOG treatment trials on population survival

J Unger;M LeBlanc;C Blanke J Clin Oncol 35, 2017 (suppl; abstr 6513); American Society of Clinical Oncology Annual Meeting (June 2-6, 2017, Chicago, IL), poster discussion


Comparison of survival outcomes among cancer patients treated in and out of clinical trials

J Unger;W Barlow;DP Martin;S Ramsey;M Leblanc;R Etzioni;D Hershman Journal of the National Cancer Institute 106(3):dju002; 2014 Mar 13 [Epub ahead of print];

PMid: PMID24627276 | PMC number: PMC3982777


Assessment of HER2 gene amplification in adenocarcinomas of the stomach or gastroesophageal junction in the INT-0116/SWOG9008 clinical trial

MA Gordon;H Gundacker;JS Macdonald;J Baranda;W Levin;C Fenoglio-Preiser;N Wick;CD Blanke;J Benedetti;W Elatre;P Weng;H Lenz;M Press Annals of Oncology 24(7):1754-1761;

PMid: PMID23524864 | PMC number: PMC3690906

Modeling the relationship between progression-free survival and overall survival: the phase 2/3 trial

M Redman;B Goldman;M LeBlanc;A Schott;LH Baker Clinical Cancer Research, 19(10):2646-2656;

PMid: PMID23669424 | PMC number: PMC4131693


Updated analysis of SWOG-directed Intergroup study 0116: a phase III trial of adjuvant radiochemotherapy versus observation following curative gastric resection (CALGB-9195; ECOG-6290; NCCTG-90-41; RTOG 9018 and SWOG-9008

S Smalley;J Benedetti;C Blanke;D Haller;S Hundahl;N Estes;JA Ajani;LL Gunderson;B Goldman;JA Martenson;JM Jessup;GN Stemmerman;JS Macdonald Journal of Clinical Oncology 30(19):2327-2333

PMid: PMID2258569 | PMC number: PMC4517071

Assessment of HER2 Gene Amplification in Adenocarcinomas of the Stomach or Gastroesophageal Junction in the INT-0116/SWOG9008 Clinical Trial

MA Gordon;H Gundacker;J Benedetti;J Macdonald;J Baranda;W Levin;N Wick;C Blanke;W Elatre;P Weng;J-Y Zhou;H Lenz;M Press J Clin Oncol 30 (suppl; abstr 4010); American Society of Clinical Oncology 2012 Annual Meeting (June 1-5, 2012, Chicago, IL), poster discussion;


Gastric Cancer: Nagoya is not New York [PMID22010021]

J Macdonald Journal of Clinical Oncology 29(33):4348-4350


Chemoradiation of resected gastric cancer: a 10 year followup of INT0116 (SWOG 9008)

J Macdonald;J Benedetti;SR Smalley;D Haller;S Hundahl;J Jessup;J Ajani;LL Gunderson;B Goldman;JA Martenson Journal of Clinical Oncology 27:15s, abst. #4515

Report from the Radiation Therapy Committee of the Southwest Oncology Group (SWOG): research objectives workshop 2008 [PMID19723641; PMC2978526]

P Okunieff;LA Kachnic;LS Constine;CD Fuller;LE Gaspar;DF Hayes;J Hooks;C Ling;FL Meyskens;PA Philip;D Raben;SR Smalley;GP Swanson;BA Teicher;CR Thomas;B Vikram;MJ Zelefsky;LH Baker Clinical Cancer Research 15(18):5663-5770


The Southwest Oncology Group: progress in cancer research [PMID18929152]

CA Coltman Seminars in Oncology 35(5):545-552


Improved regional control and survival with "low maruyama index" surgery in gastric cancer: autopsy findings from the Dutch D1-D2 trial [PMID17336241]

SA Hundahl;KCJM Peeters;EK Kranenbarg;H Hartgrink;CJH van de Velde Gastric Cancer 10(2):84-86

Gastric cancer: D2 dissection or low maruyama index-based surgery - a debate [PMID17336241]

HO Douglass;SA Hundahl;JS Macdonald;VP Khatri Surgical Oncology Clinics of North America 16(1):133-155


Low maruyama index surgery for gastric cancer [PMID17577616]

SA Hundahl Scandinavian Journal of Surgery 95(4):243-248


Evidence-based recommendations for local-regional control of gastric cancer

SA Hundahl Cancer Investigation 23(4):352-362

Chapter 45 - Stomach

SA Hundahl;JS Macdonald;SR Smalley In: Chang AE, Ganz PA, Hayes DF, et al. (eds). Oncology: An Evidence Based Approach, New York: Springer-Verlag, pgs 680-703

Changing gastric cancer treatment in the United States and the pursuit of quality

SA Hundahl;HJ Wanebo European Journal of Surgical Oncology 31(6):605-615

Low maruyama index surgery for gastric cancer: blinded re-analysis of the Dutch D1-D2 trial

KCMJ Peeters;SA Hundahl;EK Kranenbarg;H Hartgrink;CJH van de Velde World Journal of Surgery 29:1576-1584


Postoperative combined radiation and chemotherapy improves disease-free survival (DFS) and overall sirvival (OS) in resected adenocarcinoma of the stomach and gastroesophageal junction: update o fthe results of Intergroup study INT-0116 (SWOG 9008)

JS Macdonald;S Smalley;J Benedetti;N Estes;DG Haller;JA Ajani;LL Gunderson;M Jessup;JA Martenson American Society of Clinical Oncology GastrointestinaI Cancers Symposium #6

Impact of T and N stage and treatment on survival and relapse in adjuvant rectal cancer: a pooled analysis PMID:15067027

LL Gunderson;DJ Sargent;TE Tepper;N Wolmark;MJ O'Connell;M Begovic;C Allmer;L Colangelo;SR Smalley;DG Haller;JA Martenson;RJ Mayer;TA Rich;JA Ajani;JS MacDonald;CG Willett;RM Goldberg Journal of Clinical Oncology 22(10):1773-1775

Intergroup 0144: A phase III rectal surgical adjuvant study of pelvic radiation (XRT) plus 5-FU based chemotherapy (bolus 5-FU before and after PVI + XRT vs PVI before, during, and after XRT vs biochemically modulated bolus 5-FU and XRT): mature outcome results and pelvic failure analysis

S Smalley;J Benedetti;S Williamson;J Robertson;B Fisher;J Martenson;A Benson;R Mayer;C Cripps;N Estes;J Macdonald Proceedings of American Society for Therapeutic Radiology and Oncology, p. S137, abst. #14


Frequent alterations of B-catenin gene in gastric cancers with microsatellite instability

J Wang;T Shepherd;A Lowy;A Noffsinger;G Stemmermann;C Fenoglio-Preiser Proc of the American Association for Cancer Research 44(2nd.ed): #1199

Report from the Radiation Oncology Committee of the Southwest Oncology Group (SWOG): Research Objectives Workshop 2003 PMID14528084

P Okunieff;RE Meyn;BA Teicher;CR Thomas, Jr.;LE Gaspar;D Raben;S Giri;RS Lavey;AT Turrisi;GP Swanson;SR Smalley American Journal of Clinical Oncology 26(5):522-529

PMid: PMID14528084


B-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer

WM Clements;J Wang;A Sarnaik;OJ Kim;JS Macdonald;C Fenoglio-Preiser;J Groden;AM Lowy Cancer Research 62:3503-3506

B-Catenin nuclear staining and mutation in gastric cancer

OJ Kim;J Wang;WM Clements;AA Sarnaik;G Stemmermann;A Noffsinger;G DeVoe;AM Lowy;C Fenoglio-Preiser Modern Pathology 15(1):132a(#551)

Beta-catenin is commonly mutated in human gastric cancers with cyclin D overexpression.

J Wang;ONJ Kim;WM Clements;AA Sarnaik;B Liu;A Noffsinger;G Stemmermann;AM Lowy;CM Fenoglio-Preisor Proc of the American Association for Cancer Research 93:90(#526)

Mutation of the B-catenin gene is a frequent cause of Wnt pathway activation in gastric cancer.

WM Clements;J Wang;A Sarnaik;OJ Kim;JL Groden;C Fenoglio-Preiser;AM Lowy Proc of the American Association for Cancer Research 93:111(#770)

Surgical treatment variation in a prospective, randomized trial of chemoradiotherapy in gastric cancer: the effect of undertreatment.

SA Hundahl;JS Macdonald;J Benedetti;T Fitzsimmons Annals of Surgical Oncology 9(3):278-286

Surgical quality in trials of adjuvant cancer therapy

SA Hundahl Journal of Surgical Oncology 80:177-180


Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction.

JS Macdonald;SR Smalley;J Benedetti;SA Hundahl;NC Estes;GN Stemmermann;DG Haller;JA Ajani;LL Gunderson;JM Jessup;JA Martenson New England Journal of Medicine 345(10):725-730

E-Cadherin, a and b-catenins in gastric cancer expression

OJ Kim;G Stemmermann;G DeVoe;A Noffsinger;J Macdonald;C Fenoglio-Preiser Modern Pathology 14:88A(#506)

Gastric Cancer

JS Macdonald Clinical Oncology Updates 4(3):1-7


Alterations in exon 4 of the p53 gene in gastric carcinoma

T Shepherd;D Tolbert;J Benedetti;J Macdonald;G Stemmerman;J Wiest;G DeVoe;MA Miller;J Wang;A Noffsinger;C Fenoglio-Preiser Gastroenterology 118:1039-1044

Postoperative combined radiation and chemotherapy improves disease-free survival (DFS) and overall survival (OS) in resected adenocarcinoma of the stomach and G.E. junction. results of Intergroup study INT-0116 (SWOG 9008)

JS Macdonald;S Smalley;J Benedetti;N Estes;DG Haller;JA Ajani;LL Gunderson;M Jessup;JA Martenson Proc of the American Society of Clinical Oncology 19:1a(#1)

Intergroup 0116 (SWOG 9008)- Phase III trial of postoperative adjuvant radiochemotherapy for high risk gastric and gastroesophageal (GE) junction adenocarcinoma (ACA): evaluation of efficacy and radiotherapy treatment planning

S Smalley;J Benedetti;L Gunderson;J Martenson;J Tepper;K Kiel;A Lichter;J Forman;J Macdonald Int J Radiat Oncol Biol Phys 48(3)Suppl:111-112

Thioredoxin, a putative oncogene product is overexpressed in gastric carcinoma and associated with increased proliferation and increased cell survival

TM Grogan;C Fenoglio-Prieser;R Zeheb;W Bellamy;Y Frutiger;E Vela;G Stemmerman;J Macdonald;L Richter;A Gallegos;G Powis Human Pathology 31(4):475-481

A simple classification of gastric cancer

OJ Kim;G Stemmermann;A Noffsinger;C Fenoglio-Preiser Modern Pathology 13(1):83a(#474)


p53 immunoreactivity and single-strand conformational polymorphism analysis often fail to predict p53 mutational status.

DM Tolbert;AE Noffsinger;MA Miller;GW DeVoe;GN Stemmermann;JS Macdonald;CM Fenoglio-Preiser Modern Pathology 12(1):54-60

The relation of p53 gene mutations to gastric cancer subsite and phenotype.

D Tolbert;C Fenoglio-Preiser;A Noffsinger;G De Voe;J Macdonald;J Benedetti;GM Stemmermann Cancer Causes and Control 10:227-231

Alterations in exon 4 of the p53 gene in gastric cancer.

D Tolbert;AE Noffsinger;GN Stemmermann;CM Fenoglio-Preiser Proc of the American Association for Cancer Research 40:346(#2289)

Minisatellite instability in gastric cancer

YE Nikiforov;T Schulte;GN Stemmermann;AN Noffsinger;CM Fenoglio-Preiser Laboratory Investigation 79:81A(#463)


Inadequate documentation and resection for gastric cancer in the United States: A preliminary report.

NC Estes;JS Macdonald;K Touijer;J Benedetti;J Jacobson The American Surgeon 64(7):680-685


Detection of microsatellite instability and p53 gene mutations in advanced gastric carcinomas.

D Tolbert;A Noffsinger;G Stemmermann;C Fenoglio-Preiser International Academy of Pathology Book of Abstracts :65A(#369)


Immunohistochemical analysis of bcl-2 family proteins in adenocarcinomas of the stomach.

M Krajewska;CM Fenoglio-Preiser;JS Macdonald;G Stemmerman;JC Reed American Journal of Pathology 149(5):1449-1457

Pathologic and phenotypic features of gastric cancer.

CM Fenoglio-Preiser;AE Noffsinger;J Belli;GN Stemmermann Seminars in Oncology 23(3):292-306

Other Clinical Trials

SWOG Clinical Trial Number

Combined Therapies for Squamous Cell Carcinoma of the Esophagus

Research Committee(s)
Gastrointestinal Cancer
SWOG Clinical Trial Number
SWOG-8591(NCI Intergroup #0035)

An Evaluation of Levamisole Alone or Levamisole plus 5-Fluorouracil as Surgical Adjuvant Treatment for Resectable Adenocarcinoma of the Colon

Research Committee(s)
Gastrointestinal Cancer
SWOG Clinical Trial Number

A Phase II Trial of Trimetrexate in the Treatment of Esophageal Cancer

Research Committee(s)
Gastrointestinal Cancer