A Phase II 19F Magnetic Resonance Spectroscopy (MRS) Study of 5-FU and Correlation with Clinical Results of 5-FU/Leucovorin (LV) Therapy in Patients with Carcinomas of the Gastrointestinal Tract

Does leucovorin alter the intratumoral pharmacokinetics of 5-fluorouracil (5-FU)? a Southwest Oncology Group study

CA Presant;J Jacobson;W Wolf;V Waluch;IC Weitz;JS Macdonald Investigational New Drugs 20:369-376

Effects of leucovorin (LV) on the intratumoral (IT) pharmacokinetics (PK) of 5-fluorouracil (5-FU) - a Southwest Oncology Group study

W Wolf;CA Presant;V Waluch;I Weitz;J Jacobson Proc of the American Association for Cancer Research 41:611(#3885)

Spectroscopic evaluation of intratumoral (IT) metabolic modulation (MM) of 5-fluorouracil (5-FU) by leucovorin (LV): Correlation of human tumor pharmacokinetics (PK) with modulation and tumore response. SWOG 9006

CA Presant;W Wolf;V Waluch;I Weitz;J Jacobson Proc of the American Society of Clinical Oncology 19:194a(#754)

Mechanism of 5-fluorouracil trapping in tumors - a possible model for a general process determining drug uptake.

W Wolf;CA Presant;V Waluch American Association for Cancer Research 35:432(#2577)

Association of intratumoral pharmacokinetics of fluorouracil with clinical response

CA Presant;W Wolf;V Waluch;C Wiseman;P Kennedy;D Blayney;RR Brechner Lancet 343:1184-1187

Measurement of human tumor pharmacokinetics in vivo noninvasively by 19-F magnetic resonance spectroscopy predicts clinical 5-FU sensitivity and resistance

CA Presant;W Wolf;V Waluch;R Brechner;C Wiseman;DW Blayney;P Kennedy Cancer Treatment Update:757-758

Comparison between noninvasive nuclear imaging and nuclear magnetic resonance spectroscopy (NMRS) to monitor drug biodistribution, targeting and metabolism

W Wolf;V Waluch;CA Presant;J Dowell;H Kim;A Sancho;D Palekar 6th Meeting of World Congress of Nuclear Medicine :

Modulation of intratumoral (IT) 5FU pharmacokinetics (PK) by leucovorin (LV) and methotrexate (M) documented by 19F-magnetic resonance spectroscopy (MRS) initial results of Southwest Oncology Group studies 9006 and 9118.

CA Presant;M Wolf;V Waluch;B Ardalan;R Brechner;C Wiseman;DW Blayney;P Kennedy ASCO 12:201(#596)

Dynamic multinuclear chemical shift imaging of tumors (H-1), F-19, P-31) during 5-fluorouracil chemotherapy

H Kim;V Waluch;M Singh;CA Presant;W Wolf IEEE :1316-1318

Comparison between localized and unlocalized 1 9F NMR spectroscopy for 6-fluorouracil pharmacokinetic patient studies.

V Waluch;CA Presant;W Wolf Society of Magnetic Resonance in Medicine 11:58

The use of MRS to monitor drug biodistribution, targeting and metabolism

W Wolf;CA Presant;V Waluch Presented at the 17th LH Gray Conference on Tumor Biology-April 12-16