SWOG clinical trial number
SWOG-8710 (INT-0080) (EST-1887) (CALGB-8891)

Trial of Cystectomy Alone Versus Neoadjuvant M-VAC +Cystectomy in Patients with Locally Advanced Bladder Cancer

Closed
Phase
Accrual
100%
Published
Abbreviated Title
Local Bladder
Activated
08/01/1987
Closed
07/01/1998

Research committees

Genitourinary Cancer

Treatment

MVAC

Publication Information Expand/Collapse

2021

Neoadjuvant chemotherapy in bladder cancer: Clinical benefit observed in prospective trials computed with restricted mean survival times

Z McCaw;A Odisho;H Chaparala;M Yin;J Cloyd;R Svatek;WE Carson;CT Lee;D Sundi Urologic Oncology (Seminars and Original Investigations) Jul;39(7):435.e17-435.e22

PMid: PMID33436327

2020

Economic evaluations in NCI-sponsored network cancer clinical trials

VT Nghiem;R Vaidya;GH Lyman;DL Hershman;SD Ramsey;JM Unger Value in Health Dec;23(12):1653-1661. doi: 10.1016/j.jval.2020.08.2095. Epub 2020 Oct 9

PMid: PMID33248521 | PMC number: PMC8262264

Association of Patient Demographic Characteristics and Insurance Status with Survival in Cancer Randomized Clinical Trials with Positive Findings

JM Unger;CD Blanke;M Leblanc;W Barlow;R Vaidya;M Fleury;SD Ramsey;DL Hershman JAMA Network Open Apr 1;3(4):e203842

PMid: PMID32352530 | PMC number: PMC7193331

2018

Value of Anti-Cancer Drugs in SWOG Phase III Clinical Trials: Evidence from Multiple Evaluation Mechanisms

V Nghiem;R Vaidya;M Banegas;D Hershman;J Unger AcademyHealth Annual Research Meeting (June 23-26, 2018, Seattle, WA), poster #B-335

2017

The effect of positive SWOG treatment trials on survival of patients with cancer in the US population

JM Unger;M Leblanc;CD Blanke JAMA Oncology Oct 1;3(10):1345-1351

PMid: PMID28586789; PMC5710507

The impact of positive SWOG treatment trials on population survival

J Unger;M LeBlanc;C Blanke J Clin Oncol 35, 2017 (suppl; abstr 6513); American Society of Clinical Oncology Annual Meeting (June 2-6, 2017, Chicago, IL), poster discussion

2016

Validating a local failure risk stratification for use in prospective studies of adjuvant radiation therapy for bladder cancer

B Baumann;J He;W Hwang;KN Tucker;JE Bekelman;H Herr;SP Lerner;TJ Guzzo;SB Malkowicz;J Christodouleas International Journal of Radiation Oncology, Biology, and Physics, Jun 1;95(2):703-706

PMid: PMID27020106 | PMC number: PMC5126649

Neutrophil-to-lymphocyte ratio as a bladder cancer biomarker: Assessing prognostic and predictive value in SWOG 8710

E Ojerholm;A Smith;W-T Hwang;B Baumann;KN Tucker;SP Lerner;R Mamtani;B Boursi;JP Christodouleas Cancer 2017 Mar 1;123(5):794-801; Oct 27. doi: 10.1002/cncr.30422. [Epub ahead of print]

PMid: PMID27787873 | PMC number: PMC5319875

2014

Optimizing a risk stratification for local-regional failure after radical cystectomy using the SWOG 8710 cohort

B Baumann;J He;W-T Hwang;K Tucker;S Lerner;C Tangen;H Herr;T Guzzo;SB Malkowicz;JP Christodoulea Journal of Clinical Oncology 32(suppl 4; abstr297); ASCO Genitourinary Cancer Symposium, poster presentation;

Comparison of survival outcomes among cancer patients treated in and out of clinical trials

J Unger;W Barlow;DP Martin;S Ramsey;M Leblanc;R Etzioni;D Hershman Journal of the National Cancer Institute 106(3):dju002; 2014 Mar 13 [Epub ahead of print];

PMid: PMID24627276 | PMC number: PMC3982777

2013

Risk stratification for local-regional failure after cystectomy

BC Bauman;J He;H Hwang;K Tucker;SP Lerner;CM Tangen;HW Herr;T Guzzo;SB Malkowicz;J Christodouleas American Urological Association 2013 Annual Meeting, Abstract #1628; moderated poster discussion;

Robust risk stratification model predicts local-regional recurrence after radical cystectomy in different patient cohorts

B Baumann;J He;W-T Hwang;K Tucker;S Lerner;C Tangen;H Herr;T Guzzo;SB Malkowicz;J Christodouleas International Journal of Radiation Oncology * Biology * Physics 87(2):Supplement, p. S82; ASTRO annual meeting Sept. 22-25, 2013, Atlanta, GA), oral presentation;

2011

Do mixed histologic features affect survival benefit from neo-adjuvant platinum-based combination chemotherapy in patients with locally advanced bladder cancer treated with radical cystectomy? A secondary analysis of Southwest Oncology Group-directed intergroup study (S8710) [PMID 21105991; PMC3117124

E Scosyrev;B Ely;EM Messing;VO Speights;HB Grossman;DP Wood;RW de Vere White;NJ Vogelzang;DL Trump;RB Natale;CM Tangen;ED Crawford;IM Thompson British Journal of Urology Internatonal, 108(5):693-699;

2010

Do mixed histologic features affect survival benefit from neo-adjuvant platinum-based combination chemotherapy in patients with locally advanced bladder cancer?

E Scosyrev;B Ely;EM Messing;VO Speights;HB Grossman;DP Wood;R de Vere White;N Vogelzang;D Trump;R Natale;C Tangen;ED Crawford;IM Thompson Journal of Urology 183(4):suppl. E659 (abstr #1708); AUA 2010 Annual Meeting;poster

Do mixed histologic features affect survival benefit from neoadjuvant platinum-based combination chemotherapy in patients with locally advanced bladder cancer?

EM Messing;E Scosyrev;HB Grossman;R de Vere White;DL Trump;RB Natale;C Tangen;ED Crawford;IM Thompson ASCO 2010 Genitourinary Cancers Symposium, abstr. #274; oral

2009

Quality of pathologic response and surgery correlate with survival for completely resected bladder cancer following neoadjuvant MVAC

G Sonpavde;B Goldman;VO Speights;SP Lerner;DP Wood;NJ Vogelzang;DL Trump;RB Natale;HB Grossman;ED Crawford ASCO 2009 GU Cancers Symposium, abst. #249

Quality of pathologic response and surgery correlate with survival for completely resected bladder cancer following neoadjuvant chemotherapy. 2009 [PMID19517476; PMC3079554]

G Sonpavde;B Goldman;VO Speights;SP Lerner;DP Wood;SP Lerner;DL Trump;RB Natale;HB Grossman;ED Crawford Cancer 115(18):4104-4109

2008

The Southwest Oncology Group: progress in cancer research [PMID18929152]

CA Coltman Seminars in Oncology 35(5):545-552

2005

Optimal combined modality treatment improves outcome of locally advanced bladder cancer: analyis of SWOG 8710

ZA Dotan;DF Bajorin;BH Grossman;HW Herr Proc of the ASCO, JCO 23(16S):385s (#4531)

2004

Surgical factors influence bladder cancer outcomes: a Cooperative Group report

HW Herr;JR Faulkner;HB Grossman;RB Natale;R de Vere White;MF Sarosdy;ED Crawford Journal of Clinical Oncology 22(14):2781-2789

Pathologic evaluation of radical cystectomy specimens: a Cooperative Group report

HW Herr;JR Faulkner;HB Grossman;ED Crawford Cancer 100(11):2470-2475

2003

Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer

HB Grossman;RB Natale;CM Tangen;VO Speights;NJ Vogelzang;DL Trump;RW de Vere White;MF Sarosdy;DP Wood Jr;D Raghavan;ED Crawford New England Journal of Medicine 349(9):859-866

Surgical variables impact bladder cancer outcomes: a cooperative group report.

HW Herr;J Faulkner;HB Grossman;ED Crawford Proc of the American Society of Clinical Oncology 22:383(#1540)

Southwest Oncology Group studies in bladder cancer

ED Crawford;DP Wood;DP Petrylak;J Scott;CA Coltman, Jr;D Raghavan Cancer Supplement 97(8):2099-2108

2001

SWOG 8710 (INT-0080): randomized phase III trial of neoadjuvant MVAC + cystectomy versus cystectomy alone in patients with locally advanced bladder cancer.

D Crawford;B Grossman;B Blumenstein;N Vogelzang;D Trump;VO Speights;R DeVere White;R Natale Journal of Urology 165(5)Suppl:260(#1069)

SWOG 8710 (INT-0080): randomized phase III trial of neoadjuvant MVAC + cystectomy versus cystectomy alone in patients with locally advanced bladder cancer

RB Natale;HB Grossman;B Blumenstein;N Vogelzang;DL Trump;VO Speights;R deVere White;ED Crawford Proc of the American Society of Clinical Oncology 20:2a(#3)

Other Clinical Trials

SWOG Clinical Trial Number
S2210

S2210, "Targeted Neoadjuvant Treatment for Patients with Localized Prostate Cancer and Germline DNA Repair Deficiency"

Research Committee(s)
Genitourinary Cancer
Activated
08/14/2023
Accrual
2%
Open
Phase
SWOG Clinical Trial Number
S2200
SWOG Clinical Trial Number
CTSU/A031901