Evaluation of the Combination of Docetaxel (Taxotere®)/ Carboplatin in Patients with Metastatic or Recurrent Squamous Cell Carcinoma of the Head and Neck (SCCHN), Phase II

Closed

Phase

Accrual

97%

Published

Abbreviated Title

Recurrent, Refractory or Metastatic

Activated

11/15/1999

Closed

01/01/2001

Participants

NCORP, Members, Medical Oncologists

Research committees

Head and Neck Cancer

Treatment

Dexamethasone Docetaxel Carboplatin

Eligibility Criteria Expand/Collapse

Pts. must have histologically proven SCCHN that is met. at diag. or persisted, met. or recurred following definitive surgery and/or RT . Newly diag. non-met. dz. are not eligible. Pts. must have bidimensionally measured dz.; pts. must not have received prior chemo for recurrent dz. Pts. w/ neuropathy sensory > = Grade 2 are not eligible. Pts. w/ a hx of hypersensitivity reaction to products containing Polysorbate 80 (Tween 80) are not eligible to participate.

Publication Information Expand/Collapse

2016

Comorbidities and Risk of Chemotherapy-Induced Peripheral Neuropathy Among Participants 65 Years or Older in Southwest Oncology Group Clinical Trials

D Hershman;C Till;J Wright;D Awad;S Ramsey;W Barlow;L Minasian;J Unger Journal of Clinical Oncology Sep 1;34(25):3014-3022; 2016 Jun 20 [Epub ahead of print]

PMid: PMID27325863 | PMC number: PMC5012713

Comorbidities and risk of chemotherapy induced peripheral neuropathy among participants in SWOG clinical trials

DL Hershman;C Till;JD Wright;D Awad;S Ramsey;W Barlow;L Minasian;J Unger Journal of Clinical Oncology 34, 2016 (suppl; abstr 10001); American Society of Clinical Oncology Annual Meeting (June 3-7, 2016, Chicago, IL), oral presentation

2007

Evaluation of the combination of docetaxel/carboplatin in patients with metastatic or recurrent squamous cell carcinoma of the head and neck (SCCHN): A Southwest Oncology Group phase II study [PMID: 17530488]

WE Samlowski;J Moon;JP Kuebler;CR Nichols;DR Gandara;H Ozer;SK Williamson;JN Atkins;DE Schuller;JF Ensley Cancer Investigation 25:182-188