Standard Dose Cyclophosphamide, Doxorubicin, Vincristine, Prednisone (CHOP) and Rituximab, or Rituximab and G3139 Phosphorothioate Oligonucleotide (BCL-2 Antisense - NSC-683428) Therapy for Young Patients (< Age 60) with Advanced Stage Diffuse Large B-cell NHL of Low and Low-Intermediate IPI Risk

Previously untreated Stage III, IV or buly Stage II diffuse large B-cell non-Hodgkin's lymphoma (NHL); CD-20 positive; Path review required; Age < 60; IPI score of 0 or 1; bidimen meas dz; CT scan of chest and CT scan of abdomen/pelvis; bone marrow aspirate and biopsy; no clinical evidence of CNS involvement; no prior dx of indolent lymphoma; no prior chemo, RT or antibody tx for lymphoma; Zubrod PS 0-2; ejection fraction >/= 45% by MUGA or an echo with no significant abnormalities; LDH must be known; no known HIV; patients must not need supplemental oxygen.