SWOG clinical trial number
CTSU/EA8143

A Phase III RandOmized Study Comparing PERioperative Nivolumab Vs. Observation in Patients with Renal Cell Carcinoma Undergoing Nephrectomy (PROSPER RCC)

Closed
Phase
Abbreviated Title
Phase 3 Rando Peri-Op Nivo vs. Obs for RC Carcinoma w/ Nephrectomy
Status Notes
This study is close to accrual effective June 9, 2021.
Activated
02/02/2017
Closed
06/09/2021
Participants
CTSU

Research committees

Genitourinary Cancer

Treatment

Nivolumab

Publication Information Expand/Collapse

2024

Perioperative nivolumab versus observation in patients with renal cell carcinoma undergoing nephrectomy (PROSPER ECOG-ACRIN EA8143): an open-label, randomised, phase 3 study

M Allaf;S Kim;V Master;D McDermott;L Harshman;L Harshman;S Cole;C Drake;S Signoretti;S Signoretti;M Akgul;N Baniak;E Li-Ning;M Palmer;H Emamekhoo;N Adra;H Kaimakliotis;Y Ged;P Pierorazio;E Abel;M Bilen;K Ogan;H Moon;K Ramaswamy;E Singer;T Mayer;J Lohrey;V Margulis;J Gills;S Delacroix;M Waples;A James;P Wang;T Choueiri;M Michaelson;A Kapoor;D Heng;B Shuch;B Leibovich;P Lara;J Manola;D Maskens;D Battle;R Uzzo;G Bratslavsky;N Haas;M Carducci Lancet Oncology Aug;25(8):1038-1052

PMid: PMID38942046 | PMC number: PMC11323681

2021

PROSPER: Phase III RandOmized Study Comparing PERioperative Nivolumab versus Observation in Patients with Renal Cell Carcinoma (RCC) Undergoing Nephrectomy (ECOG-ACRIN EA8143)

M Allaf;S Kim;V Master;D McDermott;C Drake;S Signoretti;D Cella;R Gupta;S Cole;B Shuch;P Lara;A Kapoor;D Heng;B Leibovich;M Michaelson;T Choueiri;M Jewett;D Maskens;L Harshman;M Carducci;N Haas J Clin Oncol 39, 2021 (suppl 15; abstr TPS4596) (American Society of Clinical Oncology Annual Meeting 2021, poster session)

2020

PROSPER: A phase III randomized study comparing perioperative nivolumab (nivo) vs. observation in patients with localized renal cell carcinoma (RCC) undergoing nephrectomy (EA8143): A trial of the ECOG-ACRIN Cancer Research Group

L Harshman;A Puligandla;N Haas;M Allaf;C Drake;D McDermott;S Signoretti;D Cella;R Gupta;B Shuch;T Choueiri;P Lara;A Kapoor;D Heng;M Jewett;V Master;M Michaelson;B Leibovich;D Maskens;M Carducci J Clin Oncol 38: 2020 (suppl; abstr TPS5101); American Society of Clinical Oncology 2020 Annual Meeting, poster

2019

PROSPER: A phase III randomized study comparing perioperative nivolumab (nivo) vs. observation in patients with localized renal cell carcinoma (RCC) undergoing nephrectomy (ECOG-ACRIN 8143)

L Harshman;A Puligandla;N Haas;M Allaf;C Drake;D McDermott;S Signoretti;D Cella;RT Gupta;B Shuch;T Choueiri;PN Lara;A Kapoor;D Heng;M Jewett;V Master;M Michaelson;B Leibovich;D Maskens;M Carducci ASCO GU Cancers Symposium (Feb 14-16, 2019, San Francisco, CA), poster

PROSPER: A phase III randomized study comparing perioperative nivolumab (nivo) vs. observation in patients with renal cell carcinoma (RCC) undergoing nephrectomy (ECOGACRIN 8143)

L Harshman;M Puligandla;N Haas;M Allaf;CD Drake;DF McDermott;S Signoretti;D Cella;RT Gupta;B Shuch;T Choueiri;PN Lara;A Kapoor;D Heng;M Jewett;V Masters;M Michaelson;B Leibovich;D Maskens;M Carducci J Clin Oncol 37(suppl; abstr TPS4597); ASCO (5/31-6/4/19, Chicago IL) TIPS, poster session

The future of perioperative therapy in advanced renal cell carcinoma: how can we PROSPER?

HD Patel;M Puligandla;B Shuch;B Leibovich;A Kapoor;V Master;C Drake;DY Heng;PN Lara;T Choueiri;T Maskens;EA Singer;EC Eggener;RS Svatek;WM Stadler;S Cole;S Signoretti;RG Gupta;MD Michaelson;DF McDermott;D Cella;LI Wagner;NB Haas;MA Carducci;LC Harshman;ME Allaf Future Oncology May;15(15):1683-1695

PMid: PMID30968729 | PMC number: PMC6595543

2018

PROSPER: A phase III randomized study comparing perioperative nivolumab (nivo) vs. observation in patients with localized renal cell carcinoma (RCC) undergoing nephrectomy (ECOG-ACRIN 8143)

L Harshman;M Puligandla;NB Haas;M Allaf;CG Drake;DF McDermott;S Signoretti;D Cella;RT Gupta;R Satish Bhatt;E Mendel Van Allen;T Choueiri;P Lara;A Kapoor;D Yick;C Heng;B Shuch;MAS Jewett;DJ George;M Dror Michaelson;MA Carducci J Clin Oncol 36, 2018 (suppl; abstr TPS4597); ASCO Annual Meeting (June 1- 5, 2018, Chicago, IL), poster session

2017

A phase 3 randomized study comparing perioperative nivolumab vs. observation in patients with localized renal cell carcinoma undergoing nephrectomy (PROSPER RCC, EA8143)

LC Harshman;M Puligandla;N Haas;M Allaf;D McDermott;S Signoretti;R Gupta;TK Choueiri;P Lara;A Kapoor;D Heng;B Shuch;M Jewett;D George;D Michaelson;R Bhat;E Van Allen;V Master;MA Carducci J Clin Oncol 35, 2017 (suppl; abstr TPS4596);American Society of Clinical Oncology (ASCO) Annual Meeting (June 2-6, 2017, Chicago, IL), poster session (TIP)

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