SWOG clinical trial number
C19801

A Phase II Study of 506U78 in Patients with Refractory or Relapsed T-Lineage Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LBL)

Closed
Phase
Published
Abbreviated Title
Relpased/Refractory T-lineage ALL/LBL
Activated
06/15/2000
Closed
09/12/2001
Participants
NCORP, Members, Pathologists

Research committees

Leukemia
Lymphoma

Treatment

506U78

Eligibility Criteria Expand/Collapse

Histologic diagnosis of T-lineage ALL or lymphoblastic lymphoma (LBL), refractory to at least one induction treatment regimen or in first or later relapse after achieving CR; no CNS leukemia, no history of seizure disorder or > / = Grade 3 neurologic toxicity during prior treatment of ALL/LBL. No pre-existing neuropathy >/= Grade 2 at the time of registration regardless of causality; age >/= 16 years.

Publication Information Expand/Collapse

2007

Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801

DJ DeAngelo;D Yu;JL Johnson;SE Coutre;RM Stone;AT Stopeck;JP Gockerman;BS Mitchell;FR Appelbaum;RA Larson Blood 109(12):5136-5142

PMid: PMID17344466 | PMC number: PMC1941786

2002

A phase II study of 2-amino-9-B-D-arabinosyl-6-methoxy-9H-purine (506U78) in patients with relapsed or refractory T-lineage acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LBL): CALGB study 19801.

DJ De Angelo;D Yu;RK Dodge;SE Coutre;BS Mitchell;RM Stone;AT Stopeck;RA Larson Blood 100(11):198a(#743)

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