SWOG clinical trial number
SWOG-9400
Treatment of Adult Lymphoblastic Leukemia: A Phase II Trial of An Induction Regimen Including PEG-L-Asparaginase in Previously Untreated Patients, Followed By Allogeneic Bone Marrow Transplantation or Further Chemotherapy In First Complete Remission
Abbreviated Title
Treatment of Adult Lymphoblastic Leukemia: A Phase II Trial of An Induction Regimen Including PEG-L-Asparaginase in Previously Untreated Patients, Followed By Allogeneic Bone Marrow Transplantation…
Treatment
Cytosine Arabinoside
Cyclophosphamide
Prednisone
Dexamethasone
Vincristine
6-Mercaptopurine
6-Thioguanine
Adriamycin®
Allopurinol
Cyclosporine
Daunomycin
L-Asparaginase
Leucovorin Calcium
Methotrexate
Trimethoprim sulfa
VP-16
Morphologically confirmed diagnosis of ALL with FAB class L1-L2 or of mixed lineage ALL; SWOG PS 0-3, no prior remission induction chemo. for ALL, SGOT <= 3 x IULN; pts. w/ chronic liver disease or symptomatic CHF are not eligible; Slides for pathology and specimens for cytogenetics and cellular & molecular studies must be submitted.
2016
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
Gu Z;M Churchman;K Roberts;Y Li;R Harvey;K McCastlain;S Reshmi;D Payne-Turner;I Iacobucci;Y Shao;IM Chen;M Valentine;D Pei;K Mungall;A Mungall;Y Ma;R Moore;M Marra;E Stonerock;J Gastier-Foster;M Devidas;Y Dai;B Wood;M Borowitz;E Larsen;K Maloney;L Mattano;A Angiolillo;W Salzer;M Burke;F Gianni;O Spinnelli;JP Radich;MD Minden;A Moorman;B Patel;A Fielding;J Rowe;S Luger;R Bhatia;I Aldoss;SJ Forman;J Kohlschmidt;K Mrozek;G Marcucci;C Bloomfield;W Stock;W Kornblau;H Kantarjian;M Konopleva;E Paietta;C Willman;M Loh;S Hunger;C Mullighan Nature Communications Nov 8;7:13331
PMid: PMID27824051 | PMC number: PMC5105166
2011
Outcome and incidence of hyperdiploidy and hypoploidy in adults with newly diagnosed acute lymphocytic leukemia
A Advani;H Gundacker;M Slovak;K Thiel;S Forman;J Radich;F Appelbaum Blood 118:abst. #2555; American Society of Hematology, poster presentation
2010
Analysis of CRLF2/JAK expression and mutation status in adult ALL patients
O Sala-Torra;G Pogosov;E Pogosova-Agadjanyan;H Gundacker;S Forman;S O'Donnell;F Appelbaum;C Willman;JP Radich Blood 116:Abstract 758; American Society of Hematology Annual Meeting; oral
2008
Impact of cytogenetics on the outcome of adult acute lymphoblastic leukemia: results of Southwest Oncology Group study SWOG-9400 [PMC2254550;
PMID18156492]
V Pullarkat;ML Slovak;KJ Kopecky;SJ Forman;FR Appelbaum Blood 111:2563-2572
2007
Connective tissue growth factor (CTGF) expression and outcome in adult patients with acute lymphoblastic leukemia [PMID17170128; PMC1852221]
O Sala-Torra;HM Gundacker;DL Stirewalt;PA Ladne;EL Pogosova-Agadjanyan;ML Slovak;CL Willman;S Heimfeld;DH Boldt;JP Radich Blood 109(7):3080-3083
2005
CTFG (CCN2) predicts OS and DFS in adult acute lymphoblastic leukemia
O Sala-Torra;H Gundacker;DL Stirewalt;PA Ladne;EL Pogosova-Agadjanyan;ML Slovak;CL Willman;S Heimfeld;DH Boldt;JP Radich Blood (ASH Annual Meeting Abstracts) 106(11): #336
2003
Clinical significance of cytogenetic abnormalities in adult acute lymphoblastic leukemia (ALL): a Southwest Oncology Group (SWOG) study (S9400)
ML Slovak;KJ Kopecky;H Gundacker;F Appelbaum;DH Boldt;V Pullarkat;SJ Forman Blood 102(11):(#2223)
2002
Analysis of multidrug resistance gene-1 (MDR1) expression and function in adult acute lymphoblastic leukemia (ALL). a Southwest Oncology Group (SWOG) study.
DH Boldt;H Gundaker;DY Lee;Y Gazitt;SJ Forman Blood 100(11):756a(#2991)
2000
Cell cycle regulatory gene abnormalities are important determinants of leukemogenesis and disease biology in adult a2000 Apr 1;95(7):2364-71.cute lymphoblastic leukemia
W Stock;T Tsai;C Golden;C Rankin;D Sher;ML Slovak;MG Pallavicini;JP Radich;DH Boldt Blood Apr 1;95(7):2364-71
1998
Functional MDR1 expression in adult acute lymphoblastic leukemia (ALL).
Y Gazitt;D Lee;ME Wang;DH Boldt Blood 92(10)(Suppl.1):676a(#2788)
