A Phase III Randomized Study Comparing Busulfan – Total Body Irradiation Versus Cyclophosphamide – Total Body Irradiation Preparative Regimen in Patients with Advanced Myelodysplastic Syndrome (MDS) or MDS – Related Acute Myeloid Leukemia (AML) Undergoing HLA-Identical Sibling Peripheral Blood Stem Cell Transplantation, (A BMT Study)

Diagnosis of MDS or MDS-related AML subclassifiable according to the criteria in Sections 4.0 and 5.1 of the protocol; previously untreated for MDS or MDS-related AML; patients must be between the ages of 16-55; Zubrod PS 0-2, must have a genotypically HLA-identical matched sibling (at least 4 major antigen matches) and be HIV negative.