Clinical Trials
Closed
Phase
Accrual
100%
SWOG Clinical Trial Number
S1416
Phase II Randomized Placebo-Controlled Trial of Cisplatin with or without ABT-888 (Veliparib) in Metastatic Triple-Negative Breast Cancer (TNBC) and/or BRCA Mutation-Associated Breast Cancer, with or without Brain Metastases
Status Notes
S1416 will permanently close to accrual on 6/15/19.
Research Committee(s)
Breast Cancer
Activated
07-07-2016
Closed
06-15-2019
Closed
Phase
Accrual
100%
SWOG Clinical Trial Number
S1417CD
Implementation of a Prospective Financial Impact Assessment Tool in Patients with Metastatic Colorectal Cancer
Research Committee(s)
Cancer Care Delivery
Gastrointestinal Cancer
Activated
04-15-2016
Closed
02-01-2019
ClinicalTrials.gov Registry Number
NCT02728804
Closed
Phase
Accrual
100%
SWOG Clinical Trial Number
S1500
A Randomized, Phase II Efficacy Assessment of Multiple MET Kinase Inhibitors (Cabozantinib [NSC #761968], Crizotinib [NSC #749005], Savolitinib [NSC #785348], and Sunitinib [NSC #736511])in Metastatic Papillary Renal Carcinoma (PAPMET)
Status Notes
Arms 3 and 4 of the study referenced above are permanently closed to accrual effective 12/5/18. Arms 1 and 2 are active to accrual effective 1/22/19.
Research Committee(s)
Genitourinary Cancer
Activated
04-05-2016
ClinicalTrials.gov Registry Number
NCT02761057
Closed
Phase
Accrual
79%
SWOG Clinical Trial Number
S1400I
A BIOMARKER-DRIVEN MASTER PROTOCOL FOR PREVIOUSLY TREATED SQUAMOUS CELL LUNG CANCER - A PHASE III RANDOMIZED STUDY OF NIVOLUMAB PLUS IPILIMUMAB VERSUS NIVOLUMAB FOR PREVIOUSLY TREATED PATIENTS WITH STAGE IV SQUAMOUS CELL LUNG CANCER AND NO MATCHING BIOMARKER
Status Notes
Effective 3:00 p.m. Pacific Time on April 23, 2018, S1400I will be permanently closed to accrual.
This is a potential FDA registration study. There will be additional centralized and on-site monitoring conducted in addition to routine audits. Sites must also maintain a study specific Trial Master File for this study (https://swog.org/Visitors/QA/Index.asp).
This is a potential FDA registration study. There will be additional centralized and on-site monitoring conducted in addition to routine audits. Sites must also maintain a study specific Trial Master File for this study (https://swog.org/Visitors/QA/Index.asp).
Research Committee(s)
Lung Cancer
Activated
12-18-2015
Closed
04-23-2018
Closed
Phase
Accrual
98%
SWOG Clinical Trial Number
S1404
A Phase III Randomized Trial of Physician/Patient Choice of Either High Dose Interferon or Ipilimumab to MK-3475 (Pembrolizumab) in Patients with High-Risk Resected Melanoma -
Status Notes
Step 2 (randomization) of the above-referenced study will be permanently closed to accrual effective November 2, 2017 at 11:59 p.m. Pacific Time.
Closure to Step 1 (prestudy screening) was effective August 15th.
NOTE: This is a potential FDA registration study. There will be additional centralized and on-site monitoring conducted in addition to routine audits. Sites must also maintain a study specific Trial Master File for this study (https://swog.org/Visitors/QA/Index.asp).
Closure to Step 1 (prestudy screening) was effective August 15th.
NOTE: This is a potential FDA registration study. There will be additional centralized and on-site monitoring conducted in addition to routine audits. Sites must also maintain a study specific Trial Master File for this study (https://swog.org/Visitors/QA/Index.asp).
Research Committee(s)
Melanoma
Symptom Control and Quality of Life
Activated
10-15-2015
ClinicalTrials.gov Registry Number
NCT02506153
Closed
Phase
Accrual
98%
SWOG Clinical Trial Number
S1505
A Randomized Phase II Study of Perioperative mFOLFIRINOX versus Gemcitabine/nab-Paclitaxel as Therapy for Resectable Pancreatic Adenocarcinoma
Status Notes
S1505 is now closed to accrual as of 04/20/2018.
Research Committee(s)
Gastrointestinal Cancer
Activated
10-12-2015
ClinicalTrials.gov Registry Number
NCT02562716
Closed
Phase
Accrual
29%
SWOG Clinical Trial Number
S1403
A Randomized Phase II Trial of Afatinib Plus Cetuximab Versus Afatinib Alone In Treatment-Naïve Patients With Advanced, EGFR Mutation Positive Non-Small Lung Cancer (NSCLC)
Status Notes
This study permanently closed to accrual effective April 23, 2018.
Research Committee(s)
Lung Cancer
Activated
03-25-2015
Closed
04-23-2018
Closed
Phase
Accrual
100%
SWOG Clinical Trial Number
S1316
Prospective Comparative Effectiveness Trial for Malignant Bowel Obstruction
Status Notes
Re-Activation - Effective 6/1/18
Research Committee(s)
Cancer Survivorship
Gastrointestinal Cancer
Activated
03-09-2015
ClinicalTrials.gov Registry Number
NCT02270450
Closed
Phase
Accrual
98%
SWOG Clinical Trial Number
S1318
A Phase II Study of Blinatumomab (NSC-765986) and POMP (Prednisone, Vincristine, Methotrexate, 6-Mercaptopurine) for Patients >/= 65 Years of Age with Newly Diagnosed Philadelphia Chromosome Negative (Ph-) Acute Lymphocytic Leukemia (ALL) and of Dasatinib (NSC-732517), Prednisone and Blinatumomab for Patients >/= 65 Years of Age with Newly Diagnosed Philadelphia-Chromosome Positive (Ph+) ALL, and Philadelphia-Chromosome-Like Signature (Ph-Like) ALL (Newly Diagnosed or Relapsed/Refractory) with Known or Presumed Activating Dastainib-Sensitive Mutations or Kinase Fusions (DSMKF)
Research Committee(s)
Leukemia
Activated
01-12-2015
Closed
09-29-2021
ClinicalTrials.gov Registry Number
02143414
Closed
Phase
Accrual
100%
SWOG Clinical Trial Number
S1406
Randomized Phase II Study of Irinotecan and Cetuximab with or without Vemurafenib in BRAF Mutant Metastatic Colorectal Cancer
Research Committee(s)
Gastrointestinal Cancer
Activated
11-13-2014
Closed
04-01-2016
ClinicalTrials.gov Registry Number
NCT02164916
Closed
Phase
Accrual
1%
SWOG Clinical Trial Number
S1300
A Randomized, Phase II Trial of Crizotinib Plus Pemetrexed Versus Pemetrexed Monotherapy in ALK-Positive Non-Squamous NSCLC Patients Who Have Progressed Systemically After Previous Clinical Benefit from Crizotinib Monotherapy
Status Notes
This study will permanently close to accrual on September 1, 2016 at 11:59 p.m. Pacific.
Research Committee(s)
Lung Cancer
Activated
08-01-2014
Closed
09-01-2016
ClinicalTrials.gov Registry Number
NCT #02134912
Closed
Phase
Accrual
100%
SWOG Clinical Trial Number
S1320
A Randomized Phase II Trial of Intermittent Versus Continuous Dosing Of Dabrafenib (NSC-763760) and Trametinib (NSC-763093) in BRAFV600E/K Mutant Melanoma
Status Notes
Effective 7/15/2019, Step 2 registration (randomization) is permanently closed to accrual.
<b>Effective 4/19/19, Step 1 (leadâ€in continuous dosing) will be permanently closed to accrual effective April 19, 2019 at 11:59 p.m. Pacific Time.
All patients who have consented must be registered to Step 1 (leadâ€in continuous dosing) prior to 11:59 p.m. PT on April 19, 2019 in order to be eligible to participate. This closure does not apply to Step 2 randomization</b>
<b>Effective 4/19/19, Step 1 (leadâ€in continuous dosing) will be permanently closed to accrual effective April 19, 2019 at 11:59 p.m. Pacific Time.
All patients who have consented must be registered to Step 1 (leadâ€in continuous dosing) prior to 11:59 p.m. PT on April 19, 2019 in order to be eligible to participate. This closure does not apply to Step 2 randomization</b>
Research Committee(s)
Melanoma
Activated
07-22-2014
Closed
07-15-2019
ClinicalTrials.gov Registry Number
NCT02199730
Closed
Phase
Accrual
100%
SWOG Clinical Trial Number
S1314
A Randomized Phase II Study of CO-eXpression ExtrapolatioN (COXEN)-Directed Neoadjuvant Chemotherapy for Localized, Muscle-Invasive Bladder Cancer
Research Committee(s)
Genitourinary Cancer
Activated
07-09-2014
Closed
12-01-2017
ClinicalTrials.gov Registry Number
NCT02177695
Closed
Phase
SWOG Clinical Trial Number
S1400
A BIOMARKER-DRIVEN MASTER PROTOCOL FOR PREVIOUSLY TREATED SQUAMOUS CELL LUNG CANCER (LUNG-MAP)
Status Notes
The S1400 screening protocol will close to accrual and be replaced by the new Lung-MAP screening protocol, called LUNGMAP, which will open to accrual January 28, 2019, effective 2:00 pm PST.
This is a potential FDA registration study. There will be additional centralized and on-site monitoring conducted in addition to routine audits. Sites must also maintain a study specific Trial Master File for this study (https://swog.org/Visitors/QA/Index.asp).
This is a potential FDA registration study. There will be additional centralized and on-site monitoring conducted in addition to routine audits. Sites must also maintain a study specific Trial Master File for this study (https://swog.org/Visitors/QA/Index.asp).
Research Committee(s)
LungMAP
Head and Neck Cancer
Lung Cancer
Activated
06-15-2014
ClinicalTrials.gov Registry Number
NCT02154490
Closed
Phase
Accrual
83%
SWOG Clinical Trial Number
S1400A
A BIOMARKER-DRIVEN MASTER PROTOCOL FOR PREVIOUSLY TREATED SQUAMOUS CELL LUNG CANCER (LUNG-MAP) - A PHASE II STUDY OF MEDI4736 FOR PREVIOUSLY TREATED PATIENTS WITH STAGE IV SQUAMOUS CELL LUNG CANCER AND NO MATCHING BIOMARKERS (LUNG-MAP SUB-STUDY)
Status Notes
This sub-study will be permanently closed to accrual on 12/18/15 at 2:00 p.m. Pacific
Research Committee(s)
Lung Cancer
Activated
06-15-2014
Closed
11-18-2015
Closed
Phase
Accrual
57%
SWOG Clinical Trial Number
S1400B
A BIOMARKER-DRIVEN MASTER PROTOCOL FOR PREVIOUSLY TREATED SQUAMOUS CELL LUNG CANCER - A PHASE II STUDY OF GDC-0032 (TASELISIB) FOR PREVIOUSLY TREATED PI3K POSITIVE PATIENTS WITH STAGE IV SQUAMOUS CELL LUNG CANCER
Status Notes
Effective 11:59 p.m. Pacific Time on December 12, 2016, S1400B will be permanently closed to accrual.
Research Committee(s)
Lung Cancer
Activated
06-15-2014
Closed
12-12-2016
Closed
Phase
Accrual
81%
SWOG Clinical Trial Number
S1400D
A BIOMARKER DRIVEN MASTER PROTOCOL FOR PREVIOUSLY TREATED SQUAMOUS CELL LUNG CANCER - A PHASE II STUDY OF AZD4547 FOR PREVIOUSLY TREATED FGFR-POSITIVE PATIENTS WITH STAGE IV SQUAMOUS CELL LUNG CANCER
Status Notes
Effective 11:59 p.m. Pacific Time on October 31, 2016, the following sub-study will be permanently closed to accrual.
Research Committee(s)
Lung Cancer
Activated
06-15-2014
Closed
10-31-2016
Closed
Phase
Accrual
91%
SWOG Clinical Trial Number
S1400C
A BIOMARKER-DRIVEN MASTER PROTOCOL FOR PREVIOUSLY TREATED SQUAMOUS CELL LUNG CANCER - A PHASE II STUDYOF PALBOCICLIB FOR PREVIOUSLY TREATED CELL CYCLE GENE ALTERATION POSITIVE PATIENTS WITH STAGE IV SQUAMOUS CELL LUNG CANCER
Status Notes
Effective 11:59 p.m. Pacific Time on September 1, 2016, S1400C will be permanently closed to accrual.
Research Committee(s)
Lung Cancer
Activated
06-15-2014
Closed
Phase
Accrual
3%
SWOG Clinical Trial Number
S1400E
Phase II/III Randomized Study of Rilotumumab plus Erlotinib versus Erlotinib as Second Line Therapy For Biomarker Selected Patients With Squamous Cell Lung Cancer
Status Notes
This sub-study will be permanently closed to accrual on 11/24/2014 at 2:00 p.m. Pacific
Research Committee(s)
Lung Cancer
Activated
06-15-2014
Closed
11-25-2014
Closed
Phase
Accrual
4%
SWOG Clinical Trial Number
S1222
Fulvestrant Alone Versus Fulvestrant and Everolimus Versus Fulvestrant, Everolimus and Anastrozole: A Phase III Randomized Placebo-Controlled Trial In Postmenopausal Patients With Hormone-Receptor Positive Stage IV Breast Cancer.
Status Notes
NOTE: This study is permanently closed to accrual effective 10/15/2015.
Research Committee(s)
Breast Cancer
Activated
05-09-2014
Closed
10-15-2015
ClinicalTrials.gov Registry Number
NCT02137837