SWOG clinical trial number

A Randomized Phase III Trial Comparing Early High Dose Chemoradiotherapy and an Autologous Stem Cell Transplant to Conventional Dose CHOP Chemotherapy Plus Rituximab for CD20+ B Cell Lymphomas(with Possible Late Autologous Stem Cell Transplant) for Patients with Diffuse Aggressive Non-Hodgkin's Lymphoma in the High-Intermediate and High Risk International Classification Prognostic Groups (A BMT Study)

Abbreviated Title
NON-HODGKIN'S: CHOP x 8 vs. CHOP x 6 followed by TBI/VP-6/cylophosphamide or SWOG BCV with stem cell rescue
NCORP, Members, Medical Oncologists, Radiation Oncologists, Pathologists, ECOG, CALGB, NCIC-CTG, Affiliates

Research committees



Cyclophosphamide Prednisone Vincristine BCNU Doxorubicin Rituximab VP-16 Radiation Therapy CHOP RT

Eligibility Criteria Expand/Collapse

Biopsy proven intermediate or high grade non-Hodgkin's lymphoma (Working formulation groups D through H and J) except lymphoblastic lymphoma (Working formulation group I); no transformed lymphomas; High-Intermediate or High Risk Groups; Stage III, Stage IV, or "bulky" Stage II; bidimensionally measureable disease; BM aspirate and biopsy; CT scan of chest, abdomen, and pelvis; no CNS involvement; no non-lymphoma related hepatic and/or renal dysfunction; no prior chemo for lymphoma except for one cycle of CHOP prior to registration (if so all eligibility requirements for first registration must have been completed prior to the start of the first cycle of CHOP); no prior RT for lymphoma; no coronary artery disease, cardiomyopathy, congestive heart failure, or dysrhythmia requiring therapy; no known allergy to etoposide or a history of Grade 3 hemorrhagic cystitis with cyclophosphamide; no known AIDS or HIV.

Publication Information Expand/Collapse


Autologous Transplantation as Consolidation for High Risk Aggressive T-Cell Non-Hodgkin's Lymphoma: A SWOG 9704 Intergroup Trial Subgroup Analysis

Z Al-Mansour;H Li;JR Cook;LS Constine;S Couban;DA Stewart;TC Shea;P Porcu;JN Winter;BS Kahl;S Smith;DC Marcellus;KP Barton;GM Mills;M LeBlanc;L Rimsza;SJ Forman;JP Leonard;RI Fisher;JW Friedberg;PJ Stiff Leukemia and Lymphoma Jan 10:1-8. doi: 10.1080/10428194.2018.1563691. [Epub ahead of print]

PMid: PMID30628511 | PMC number: PMC6620162


Survival by Hispanic Ethnicity among Cancer Patients Participating in SWOG Clinical Trials

M Chavez-MacGregor;J Unger;A Moseley;S Ramsey;DL Hershman Cancer Apr 15;124(8):1760-1769; Jan 25 [Epub ahead of print]

PMid: PMID29370458 | PMC number: PMC5963502


Outcomes of MYC-associated lymphomas after R-CHOP with and without consolidative autologous stem cell transplant: Subset analysis of randomized trial intergroup S9704

SD Puvvada;P Stiff;M Leblanc;JR Cook;S Couban;JP Leonard;B Kahl;D Marcellus;T Shea;JN Winter;H Li;LM Rimsza;JW Friedberg;S Smith British Journal of Haematology Sep;174(5):686-691; 2016 Apr 13 [Epub ahead of print]

PMid: PMID27072903 | PMC number: PMC5125530

Beyond RCHOP: A blueprint for diffuse large B-cell lymphoma research

GS Nowakowski;KA Blum;JW Friedberg;L Baizer;R Little;D Maloney;LH Sehn;ME Williams;W Wilson;JP Leonard;SM Smith Journal of the National Cancer Institute Dec 16;108(12). pii: djw257. Print 2016 Dec.

PMid: PMID27986884 | PMC number: pending

Autologous transplantation as consolidation for high risk aggressive t-cell non-Hodgkin’s lymphoma: a SWOG S9704 intergroup trial subgroup analysis

PJ Stiff;H Li;JR Cook;LS Constine;S Couban;DA Stewart;TC Shea;P Porcu;JN Winter;BS Kahl;SM Smith;D Marcellus;KP Barton;GM Mills;M LeBlanc;LM Rimsza;SJ Forman;JP Leonard;RI Fisher;JW Friedberg Blood 128:4651; American Society of Hematology Annual Meeting (December 3-6, 2016, San Hematology Annual Meeting (December 3-6, 2016, SanDiego, CA), poster


Genetic polymorphisms in oxidative stress-related genes are associated with outcomes following treatment for aggressive B-cell non-Hodgkin lymphoma

H Gustafson (Tardif);S Yao;B Goldman;K Lee;C Spier;M LeBlanc;L Rimsza;JR Cernan;TM Habermann;BK Link;MJ Mauer;SL Slager;D Persky;T Miller;RI Fisher;C Ambrosone;M Briehl American Journal of Hematology 89(6):639-645;

PMid: PMID24633940 | PMC number: PMC4137041

Clinical significance of MYC protein expression and/or high grade morphology in non-Burkitt, diffuse aggressive B-cell non-Hodgkin lymphomas: a SWOG S9704 correlative study

JR Cook;B Goldman;RR Tubbs;L Rimsza;M LeBlanc;P Stiff;RI Fisher American Journal of Surgical Pathology 38(4):494-501;

PMid: PMID24625415 | PMC number: PMC3955880

The role of myeloablation for lymphoma

PJ Stiff;JM Unger;RI Fisher New England Journal of Medicine 370(6):575-576

PMid: PMID24499218 | PMC number: n/a - correspondence not within the scope of Public Access Policy

Double hit lymphoma and double positive lymphoma: subset analyses of MYC positive patients of SWOG S9704

S Puvvada;P Stiff;M Leblanc;JR Cook;BS Kahl;H Li;L Rimsza;JW Friedberg;SM Smith Blood 124(21):1710; American Society for Hematology (December 6-9, 2014, San Francisco, CA), poster;


Autologous transplant as consolidation for aggressive non-hodgkin's lymphoma

P Stiff;J Unger;J Cook;L Constine;S Couban;D Stewart;T Shea;P Porcu;J Winter;BS Kahl;T Miller;R Tubbs;D Marcellus;J Friedberg;K Barton;G Mills;M Leblanc;L Rimsza;S Forman;RI Fisher New England Journal of Medicine, 369(18):1681-1690;

PMid: PMID24171516 | PMC number: PMC3985418


MYC protein expression, but not high grade morphology, is associated with poor outcome in non-Burkitt diffuse aggressive B-cell lymphomas: a SWOG S9704 correlative study

JR Cook;B Goldman;RR Tubbs;L Rimsza;M LeBlanc;P Stiff;RI Fisher Blood 120(21):abst.543; American Society of Hematology Annual Meeting, oral;


Randomized phase III US/Canadian intergroup trial (SWOG S9704) comparing CHOP+/- R x 8 vs. CHOP +/- R x 6 followed by high dose therapy and autotransplant for patients with diffuse aggressive non-Hodgkin's lymphoma (NHL) in the high-intermediate (H-Int) or high IPI risk groups

P Stiff;J Unger;J Cook;L Constine;S Couban;T Shea;JN Winter;TP Miller;RR Tubbs;D Marcellus;J Friedberg;K Barton;G Mills;M LeBlanc;L Rimsza;S Forman;RI Fisher Journal of Clinical Oncology 29:(suppl; abstr 8001); ASCO 2011 Annual Meeting, oral presentation


Diffuse large B-cell lymphomas with high grade morphologic features and/or MYC translocations lack distinctive clinicopathologic features at presentation: a SWOG S9704 study

J Cook;R Tubbs;L Rimsza;P Stiff;M LeBlanc;R Fisher;B Goldman United States and Canadian Academy of Pathology 99th Annual Meeting, abst #1308 (3/20-26, 2010, Wash DC); poster